Research In Progress

Research In Progress


CARDIOVASCULAR HEALTH

Carvajal-Zarrabal O, Nolasco-Hipolito C, Aguilar-Uscanga MG, Melo Santiesteban G, Hayward-Jones PM, Barradas-Dermitz DM. Effect of dietary intake of avocado oil and olive oil on biochemical markers of liver function in sucrose-fed rat. Biomed Res Int. 2014. Doi: 10.1155/2014/595479. Epub 2914 Apr 17.

Khor A, Grant R, Tung C, et al. Impact of avocado enriched diets on serum lipids of diabetic patients. J Cardiovasc Dis. 2013; 1: 13-14. 

Rodriguez-Sanchez DG, Flores-Garcia M, Silva-Platas C, et al. Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with anitplatelet and antithrombotic activities*. Food Funct. 2014. [Epub ahead of print]

Li Z, Wong A, Henning SM, et.al. Hass avocado modulates postprandial vascular reactivity and postprandial inflammatory responses to a hamburger meal in healthy volunteersFood Funct. 2012. DOI: 10.1039/c2fo30226h.

Carranza-Madrigal J, Herrera-Abarca JE, Alvizouri-Muñoz M, Alvarado-Jimenez MR, Chavez-Carbajal F. Effects of a vegetarian diet vs. a vegetarian diet enriched with avocado in hyper-cholesterolemic patients. Arch Med Res. 1997; 28: 537-541.

Lopez LR, Frati Munari AC, Hernández Domínguez BC, et al. Monounsaturated fatty acid (avocado) rich diet for mild hypercholesterolemia. Arch Med Res. 1996; 27: 519-523.

Carranza J, Alvizouri M, Alvarado MR, et al. [Effects of avocado on the level of blood lipids in patients with phenotype II and IV dyslipidemias]. [Spanish] Arch Inst Cardiol Mex. 1995; 65: 342-348.

Alvizouri-Munoz M, Carranza-Madrigal J, Herrera-Abarca JE, Chávez-Carbajal F, Amezcua-Gastelum JL. Effects of avocado as a source of monounsaturated fatty acids on plasma lipid levels. Arch Med Res. 1992; 23: 163-167.

Colquhoun D, Moores D, Somerset SM, Humphries JA. Comparison of the effects on lipoproteins and apolipoproteins of a diet high in monounsaturated fatty acids, enriched with avocado, and a high-carbohydrate diet. Am J Clin Nutr. 1992; 56: 671-677.

Grant WC. Influence of avocados on serum cholesterol. Proc Soc Exp Biol Med. 1960; 104: 45-47.

 


WEIGHT MANAGEMENT

Haddad E. Wien M, Schaffer T, Oda K, Sabaté J. Acute effect of avocados in meals on peptide hormones in overweight healthy adults. FASEB J. 2012; 26: 639.12.

Sabaté J, Wien M, Haddad E. Effect of incorporating avocados in meals on self-reported subjective feelings related to satiety in healthy overweight adults. FASEB J. 2012; 26: 40.3.

Pieterse Z, Jerling JC, Oosthuizen W, et al. Substitution of high monounsaturated fatty acid avocado for mixed dietary fats during an energy-restricted diet: Effects on weight loss, serum lipids, fibrinogen, and vascular function. Nutrition. 2005; 21: 67-75.

 


DIETARY PATTERNS

Fulgoni VL 3rd, Dreher M, Davenport AJ. Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008. Nutr J. 2013; 12: 1.
 

 


GLYCEMIC CONTROL IN PEOPLE WITH TYPE 2 DIABETES

Lerman-Garber I, Ichazo-Cerro S, Zamora-Gonzalez J, Cardoso-Saldana G, Posadas-Romero C. Effect of a high-monounsaturated fat diet enriched with avocado in NIDDM patients. Diab Care. 1994; 17: 311-315.

 


CANCER

Jackson MD, Walker SP, Simpson-Smith CM, et al. Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. Cancer Causes Control. 2012; 23: 23-33.

D'Ambrosio SM, Han C, Pan L, Kinghorn AD, Ding H. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting EGFR/RAS/RAF/MEK/ERK1/2 pathway. Biochem Biophys Res Commun. 2011; 409: 465-469.

Ding H, Han C, Guo D, et al. Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism. Nutr Cancer. 2009; 61: 348-356.

Ding H, Chin YW, Kinghorn AD, D'Ambrosio SM. Chemopreventive characteristics of avocado fruit. Sem Canc Biol. 2007; 17: 386-394.

Lu QY, Arteaga JR, Zhang Q, et al. Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. J Nutr Biochem. 2005; 16: 23-30.

 


SKIN UV PROTECTION AND WOUND HEALING

Rosenblat G, Meretski S, Segal J, et al. Polyhydrolylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Arch Dermatol Res. 2011; 303(4): 239-46.

Nayak BS, Raju SS, Chalapathi RAV. Wound healing activity of Persea americana (avocado) fruit: a preclinical study on rats. J Wound Care. 2008; 17(3): 123-6.

 


NUTRIENT & PHYTOCHEMICAL ABSORPTION

Kopec RE, Cooperstone JL, Schweiggert RM, et al. Avocado consumption enhances human postprandial porvitamin A absorption and conversion from a novel high-beta-carotene tomato sauce and from carrotsJ Nutr. 2014; 144(8): 1158-66.

Kopec R, Cooperstone J, Schweiggert R, et al. Provitamin A absorption and conversion from a unique high beta-carotene tomato is higher when consumed with avocado. FASEB J. 2012; 26: 31.5.

Unlu N, Bohn T, Clinton SK, Schwartz SJ. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutr. 2005; 135: 431-436.

 


NUTRIENT & PHYTOCHEMICAL COMPOSITION

Hurtado-Fernandez E, Pacchiarotta T, Mayboroda OA, Fernandez-Gutierrez A, Carrasco-Pancorbo A. Metabolic analysis of avocado fruits by GC-APCI-TOF MS: effects of ripening degrees and fruit varieties. Anal Bioanal Chem. 2014. [Epub ahead of print]

 

Esteve C, D'Amato A, Marina ML, Garcia MC, Righetti PG. Identification of avocado (Persea americana) pulp proteins by nano-LC-MS/MS via combinatorial peptide ligand libraries. Electrophoresis. 2012; 33: 2799-2805.

Villa-Rodríguez JA, Molina-Corral F J, Ayala-Zavala JF, Olivas GI, Gonzalez-Aguilar GA. Effect of maturity stage on the content of fatty acids and antioxidant activity of 'Hass' avocado. Food Research Int. 2011; 44: 1231-37.

Wang M, Zheng Y, Khuong T, Lovatt CJ. Effect of harvest date on the nutritional quality and antioxidant capacity in ‘Hass' avocado during storage. Food Chem. 2012; 135: 694-8.

Hurtado-Fernandez E, Carrasco-Pancorbo A, Fernandez-Gutierrez A. Profiling LC-DAD-ESI-TOF MS methods for the determination of phenolic metabolites from avocado (Persea americana). J Agric Food Chem. 2011; 59(6): 2255-2267.

Rodriguez-Carpena JC, Morcuende D, Andrade MJ, Kylli P, Estevez M. Avocado (Persea americana Mill.) phenolic, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. J Agric Food Chem. 2011; 59(10): 5625-5635.

Lu QY, Zhang Y, Wang Y, et al. California Hass avocado: Profiling of carotenoids, tocopherols, fatty acids, and fat content during maturation and from different growing areas. J Agric Food Chem. 2009; 57(21): 10408-10413.

U.S. Department of Agriculture, Agricultural Research Service, USDA Nutrient Data Laboratory. 2009. USDA National Nutrient Database for Standard Reference, Release 22. Avocado Composition. NDB No: 09038 (Nutrient values and weights are for edible portion)

Meyer MD, Terry LA. Development of a rapid method for the sequential extraction and subsequent quantification of fatty acids and sugar from avocado mesocarp tissue. J Agric Food Chem. 2008; 56(16): 7439-7445.

Ashton OB, Wong M, McGhie TK, et al. Pigments in avocado tissue and oil. J Agric Food Chem. 2006; 54(26): 10151-8.

Moreno AO, Dorantes L, Galindez J, Guzman RI. Effect of different extraction methods on fatty acids, volatile compounds, and physical and chemical properties of avocado (Persea americana Mill.) oil. J Agric Food Chem. 2003; 51(8): 2216-2221.

Duester KC. Avocado fruit is a rich source of beta-sitosterol. J Am Diet Assoc. 2001; 101(4): 404-405.

Duester KC. Avocados a look beyond basic nutrition for one of nature's whole foods. Nutr Today. 2000; 35(4): 151-157.

Kim OK, Murakami A, Nakamura Y, et al. Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit. J Agric Food Chem. 2000; 48(5): 1557-1563.

Oberlies N, Rogers LL, Martin JM, McLaughlin JL. Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana. J Nat Prod. 1998; 61(6): 781-785.

Rainey C, Affleck M, Bretschger K, Alfin-Slater R. The California Avocado: A New Look. Nutr Today. 1994; 29(3): 23-27.

Shaw P, Wilson CW, Knight RJ. High-performance liquid chromatographic analysis of D-manno-heptulose, perseitol, glucose, and fructose in avocado cultivars. J Agric Food Chem. 1980; 28(2): 379-382.

Slater G, Shankman S, Shepherd JS, Alfin-Slater RB. Seasonal variation in the composition of California avocados. J Agric Food Chem. 1975; 23(3): 468-474.
 


LITERATURE REVIEW STUDIES

Dreher ML, Davenport AJ. Hass avocados Composition and Potential Health EffectsCrit Rev Food Sci Nutr. 2013; 53: 738-750.